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BSc / MSc in biological sciences (Cell Biology, Molecular Biology, Immunology or a closely related discipline) with more than 20 years of experience or PhD in the same fields with more than 15 years of experience in the biotech industry, focusing on bioassay development for protein therapeutics.
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An exciting opportunity has risen for a Senior Pharmacologist to join a highly specialised contract research organisation providing pre-clinical bioassay services to support drug development programmes across pharmaceuticals and biotech companies.
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Experience with any or all of the following is considered advantageous: bioassay, spectroscopy (UV-Vis, CD, and fluorescence), mass spectrometry. Minimum B.S. degree in Analytical Chemistry, Biophysical/biochemical sciences, pharmaceutical sciences Or Master’s Degree in Biochemistry, Biotechnology, Biology.
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Conduct assays and experiments using flow cytometry, PCR, cell-based assays/bioassay development, and ELISA techniques. Demonstrated experience with standard molecular biology techniques (DNA/RNA/protein isolation, cDNA synthesis, RT-PCR, qPCR, digital PCR, western blot, and immunofluorescence.
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The opportunityThe Bioassays and Potency Analysis group strives to deliver creative medicines to patients through performance of bioassay, potency and impurities testing activities within a GxP-compliant QC laboratory to support pre-clinical studies and clinical development for biological products manufactured in a GMP production facility.
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Work with Protein Biochemistry and Structural Biology colleagues to design, generate, and characterize protein reagents needed for pre-clinical drug discovery. You are familiar with a variety of data analysis tools to analyze bioassay data (e.g. GraphPad Prism) and may have experience using or supporting data warehousing and visualization platforms (e.g. Revvity Signals/Data Factory, Spotfire, Genedata, etc.
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Act as Biochemistry group representative, collaborating closely with Chemistry, Structural Biology, Proteomics, and Biology colleagues to define strategy towards the mechanistic understanding of small molecule modulators of transcription factors to improve compound efficacy for H2L and LO advancement.
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Experiences in cell and molecular biology and immunological techniques, including cell culture, Western immunoblotting, QRT-PCR, gene transfection and cloning, RNA interference and DNA sequencing, flow cytometry-based assessment of immune system mechanisms that regulate cancer initiation, promotion and progression, the role of the tumor microenvironment in cancer immunity and novel approaches to cancer immunotherapy.
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Generates and analyzes data to support lab services: ADME Toxicology, Ion Channel, Translational Biology, Cell and Gene Therapy, and Large Molecule Services. Proven mammalian cell culture and bioassay experience with recombinant and primary cells.
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In this role, you will support QC Bioassay Labs with review of test records and documents. 5+ years of direct experience in QC Molecular testing and Cell Biology (e.g. qPCR, sequencing, potency, mammalian, and bacterial cell culture.
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The Bioassay QC Analyst 1 will be responsible for GMP release testing of products produced at Moderna’s GMP manufacturing facility and affiliated contract organizations. Support bioassay testing for raw materials, drug substance and drug product, including generation of testing data to support clinical studies.
ExpandApply NowActive JobUpdated 8 days ago - UpvoteDownvoteShare Job
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The Associate Director, QC Cell Culture and Bioassay will be responsible for overseeing a testing laboratory charged with the execution of all GMP bioassay testing (release and stability) related to Sarepta' s Gene Therapy pipeline.
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DDITIONAL SKILLS: Laboratory, Maintenance, Method Validation, GMP, QA, Radioactive, SOPs, Validation Protocols, Analytical Assays, Bioassay, Biochemistry, Cellular, Cellular Biology, Immunology, Operations, Good Documentation Practices.
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MS in Molecular Biology, Immunology, Biochemistry, Bioanalytical chemistry or related field with 2+ years of industry experience OR BS with minimum of 5+ years of experience. Support bioassay lab activities such as cell culturing, reagent acquisition and qualifications, instrument purchase and qualification.
Full-timeExpandApply NowActive JobUpdated 12 days ago - UpvoteDownvoteShare Job
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Techniques may include any or all of the following: Mammalian cell culture, Sterile technique, In vitro cell based assays (e.g. reporter gene bioassay, CellTiter-Glo bioassay, etc.) , ELISA assays, quantitative and potency (fluorescence, luminescence, colorimetric, MSD), Molecular biology (e.g. qPCR, PCR, etc.
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