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The incumbent will be responsible for drug screening, cell-based assay development, and biomarker discovery. This Associate Research Scientist will join the Translational Development Group in San Diego.
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The Clinical Biomarkers & Diagnostics (CBD) department at looking for a highly motivated Computational Biologist with expertise in clinical bioinformatics, biomarker development, assay development, algorithms & data science, statistical modeling, handling clinical data sets and a background in biology and computational sciences.
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Biology techniques (Protein, DNA and RNA isolations, Western blot, qRT-PCR, Flow Cytometry) transductions, RNA and protein preparation from cells and tissue, RT-PCR, western blotting, and. Demonstrate proficiency with sterile cell culture, cell-based assays (CTG, apoptosis) and molecular.
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Is looking for a highly motivated Computational Biologist with expertise in clinical bioinformatics, biomarker development, assay development, Client algorithms & data science, statistical modeling, handling clinical data sets and a background in biology and computational sciences.
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Experience leveraging bioinformatics and statistical analyses in clinical development and biomarker research, with preferred focus on prostate cancer and other solid tumor contexts. This is a high-visibility, individual contributor role preferring experience within matrix environments representing the function and requiring the development of methods to support the entirety of the clinical portfolio.
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In collaboration with CDx lead work with Dx partners to ensure robust development of assay, participate in HA interaction for drug-related CDx topics/questions, and attend device company HA meetings as appropriate.
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Position Summary The Senior Associate, Analytical Development will be responsible for the execution of routine testing, including but not limited to flow cytometry assay, cell-based cytotoxicity assay, or PCR-based assay, to characterize or release engineered TCR-T cell drug product.
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This position is based in San Diego, CA. Depending on experience, the scientist will expand molecular and product specific assay development working with the Gene Therapy Research and Development team.
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Apply today to join the Lilly Team Key responsibilities include : Plan and independently implement in vivo studies and in vivo assay development and optimization to support preclinical characterization and evaluation of targets/pathways that regulate energy balance.
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Support customers in experimental design and assay development activities. Research based post-graduate degree (PhD or MSc) or significant research and development experience. Keep abreast of current trends in the biochemical sciences, particularly trends in the biopharmaceutical industry, and use this to help inform Applied Photophysics’ development and marketing activities.
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Execute development, verification, and validation studies for novel diagnostic NGS assays. Prepare and document design control documentation, CDx assay requirements, functional specifications, performance and study results, and other data in a QSR-compliant manner.
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Independently initiates and carries out the process for assay development, optimization, and validation as required. Practical experience with protein quantitation (elisa-based methods, western blotting, flow cytometry (desirable.
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Ensure that all assay development activities adhere to relevant regulatory standards and guidelines, including but not limited to FDA, EMA, ICH etc. The candidate will ensure phase-appropriate assay development requirements are met, while having a line of site towards development of assays which will be robust, reproducible and capable of being qualified and validated for GMP use.
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Experience in assay development, mammalian cell culture, ELISA, Western blotting, qPCR, and experience in standard molecular biology techniques such as cloning, protein expression and purification is preferred.
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Independently manage molecular cloning experiments and assay development to construct DNA constructs and perform functional characterizations in microbial and plant systems. Knowledge of gene editing and analytical chemistry (e.g., GC, HPLC) is favorable, along with a background in protein interaction assays.
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