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Extensive working knowledge of biomarker and bioanalytical assay development and cutting-edge Omics methodologies in the clinic. Successfully manage CROs and establish relationships to develop biomarker assays, monitor assay qualification/validation at CROs, as well as bioanalytical/biomarker testing in the clinical trials.
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Procures and manages vendors to implement biomarker assay development and perform biomarker analysis. The individual will define and implement preclinical and clinical translational and biomarker strategies for product candidates entering clinical development and execute these strategies in first-in-human clinical trials.
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Use multiple platforms (such as MSD, ELISA) to support immunoassay method feasibility, assay development and qualification of biomarker assays in different matrices in support of all our preclinical and clinical programs.
$135,000 - $150,000 a yearFull-timeExpandUpdated 2 days ago - UpvoteDownvoteShare Job
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Partners with Clinical Pharmacology PK/PD/ Flow cytometric labs to oversee assay development and review qualification and validation plans, maintenance of SOPs, and identification of critical reagents.
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Participates in projects for Biomarker/IVD assay development in various disease areas. The Research Associate I will support immunodiagnostic assay development following the product development process.
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Demonstrated experience in clinical biomarker assay development, validation, clinical implementation, and data interpretation. Strong background in biomarker technologies including NGS, immunoassay, genomics, and proteomics.
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Orum Therapeutics is seeking an in vitro pharmacologist with experience in oncology preclinical drug discovery and preclinical biomarker discovery to join our dynamic and growing team in Lexington, MA. We are looking for a candidate who is excited about joining a team looking to improve the lives of patients.
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Perform integrative analysis of multiple biomarker assessments including gene expression, IHC/Multiplex IF data, safety biomarker, and drug response data for baseline and post-dose biomarker discovery for clinical programs.
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This individual will work closely with internal groups and external CROs/collaborators for tissue-based biomarker and companion diagnostics assay development and implementation. Accordingly, the Clinical Biomarkers & Diagnostics (CBD) function plays a critical role in advancing our drug development programs and is accountable for the development of biomarker and diagnostics strategy across our pipeline.
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The incumbent will be responsible for drug screening, cell-based assay development, and biomarker discovery. biology techniques (Protein, DNA and RNA isolations, Western blot, qRT-PCR, Flow Cytometry.
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Transductions , RNA and protein preparation from cells and tissue, RT-PCR, western blotting, and. Demonstrate proficiency with sterile cell culture, cell-based assays (CTG, apoptosis) and molecular. Hands on experience in working with CRISPR, siRNA and shRNA is a plus.
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Determines appropriate assays and vendors for clinical biomarkers, and manages outsourcing of biomarker assay development and validation partnering with Translational Sciences colleagues when applicable.
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The individual will be responsible for TM and clinical biomarker activities to support drug development programs in multiple diseases in neurology and immunology. Ph. D., and 5+ years of academic or biotechnology/pharmaceutical clinical experience, minimum 3 years of clinical biomarker experience.
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This is a key position in the biomarker group to manage a group of scientists and RAs to drive biomarker discovery and assay development across several projects in research and development.
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Collaborate with Discovery Research and product development teams to facilitate appropriate incorporation of Precision Medicine and clinical biomarker strategies for molecules in discovery phases (leading to candidate molecule selection.
$85ExpandApply NowActive JobUpdated 2 days ago
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