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Demonstrated expertise and hands on experience with in vitro antibody display systems (yeast, phage, mammalian, and/or nucleic acid display). Mosaic teams provide comprehensive, end-to-end discovery services, including program assessment and strategy development; program management; antibody discovery and optimization; protein production, purification, and characterization; protein engineering; biochemical and cellular assay development; formulation, stability and developability studies; bioanalytical (PK and PD) assay development; and candidate-validating pharmacology.
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Serve as DMPK and BA representative on project teams supporting the development of novel drug candidates (small molecules, possibly biologics and antibody drug conjugates) for the treatment of diseases in Oncology, and Immuno-Oncology.
$129,500 - $191,500 a yearFull-timeExpandApply NowActive JobUpdated 7 days ago - UpvoteDownvoteShare Job
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As part of our mission, TRACTION is focused on partnering with our internal drug discovery engine (IACS, ORBIT, Biologics Development and Cell Therapies) and a growing list of external Partners (Boehringer Ingelheim, Taiho, Blueprint Medicines, Schr dinger and Obsidian) to discover and develop the next generation of small-molecule targeted therapies, antibody therapeutics and cell therapies, all driven by the needs we see in our patients.
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The successful candidate is expected to be a bench associate scientist and will use a wide range of techniques in antibody discovery, screening and characterization from lead identification, optimization, and clinical candidate selection.
$97,400Full-timeExpandApply NowActive JobUpdated 2 days ago - UpvoteDownvoteShare Job
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The successful candidate will apply state-of-the-art synthetic biology and cell engineering techniques to create research cell lines for recombinant protein production to support drug candidate screening in vitro and in vivo across Gilead’s therapeutic areas including Virology, Oncology, and Inflammation.
$191,335 - $247,610ExpandApply NowActive JobUpdated 2 days ago - UpvoteDownvoteShare Job
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Performs basic Downstream purification and mRNA production activities, such as in-vitro transcription (IVT) reactions, chromatography, tangential flow filtration (TFF), viral filtration, bulk drug substance filling, and column packing/qualification.
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You will be reporting to our Chief Scientific Officer & Head of Research, and you will manage a team of research biologists and project team leaders and work across teams including Antibody and Protein Engineering, Nonclinical sciences, Tech Ops, and CMC.
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In collaboration with AbbVie About the Role: Plays a key leadership role in developing our in vitro and in vivo strategies towards target identification and drug discovery, through to clinical candidate selection.
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Performs basic Downstream purification and mRNA production activities, such as in-vitro transcription (IVT) reactions, chromatography, tangential flow filtration (TFF), viral filtration, and column packing and qualification.
Full-timeExpandApply NowActive JobUpdated 2 days ago - UpvoteDownvoteShare Job
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These scientific platforms include; Immuno-Oncology (IO), Tumor Drivers & Resistance (TDR), DNA Damage Response (DDR) and we are developing therapeutic agents across multiple modalities including; small molecules, biologics, Antibody Drug Conjugates (ADCs), nano-medicines and PROTACs.
ExpandApply NowActive JobUpdated 8 days ago - UpvoteDownvoteShare Job
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These include intellectual input and decision-making on protein targets to be pursued, development of immunogens and immunization strategies, utilization of hybridoma technology, and antibody validation in vitro and in vivo.
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In vitro phage library panning and clone screening via phage ELISA and periprep ELISA. pool DNA cloning from antibody discovery outputs. nanopore sequencing of antibodies and antibody fragments.
$29.14 - $34.29 an hourFull-timeExpandApply NowActive JobUpdated 20 days ago - UpvoteDownvoteShare Job
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You have 1-3 years of hands-on experience in antibody discovery workflows via in-vitro display technology (yeast, phage, mammalian, etc. The candidate will report directly to our Head of In Vitro Discovery and Optimization and work to support the discovery and engineering of antibody-based therapeutics and the development of novel platform technologies.
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Ability to design antibody panels for multi-color flow cytometry. Conduct in vitro experiments on 2D cells, 3D reconstructed skin or ex vivo human skin. Ability to design antibody panels for multi-color flow cytometry.
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Lead the lab through the development and execution of preclinical pharmacology immunoassays & models evaluating therapeutic antibody candidates. This position will be a critical lab-based role designing and executing immunology assays defining the pharmacology of lead antibody candidates.
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