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Support antibody expression construct generation by molecular cloning, DNA sequencing, and plasmid DNA purification. Antibody characterization/QC by SDS-PAGE, HPLC-SEC, and Gator to determine antibody quantity and quality.
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The Biologics group is responsible for various functions criticalfor drug development such as: antibody discovery, molecular biology, cell line engineering,protein engineering, biophysical analytics, and functional cell assays.
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At Genmab, we’re committed to building extra[not]ordinary futures together, by developing antibody products and pioneering, knock-your-socks-off therapies that change the lives of patients and the future of cancer treatment and serious diseases.
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Experience in molecular biology, protein engineering, protein purification, Surface Plasmon Resonance (SPR), and tissue culture. This position oversees a cutting -edge industrial scale laboratory with over $2.5M in instrumentation supporting up to 40 unique antibody discovery campaigns annually.
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Provide assistance in the execution of experiments and analytical procedures including: molecular biology, DNA cloning, cell culture, protein production, ELISA, Biolayer interferometry and HPLC.
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The successful candidate excels in a collaborative, cross-functional, matrix team environment to enable the development of new drug products for pharmaceutics, biologics, and emerging modalities such as, but not limited to, antibody-drug conjugates, gene therapy, oligonucleotides, and SiRNA nanoparticulate delivery.
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The successful applicant will drive rigorous scientific projects utilizing next-generation sequencing including single-cell RNseq and BCR-seq, molecular biology, antibody discovery and engineering, and in vivo animal modeling.
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Using new technologies, cutting-edge science, and strong internal and external partnerships, we are leveraging our expertise in antibody discovery, protein and cell engineering, and biochemistry to transform the field of neuroscience.
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Senior Research Associate/Associate Scientist, Protein Biochemistry Allakos Inc. is a clinical-stage company developing therapeutic antibodies for inhibitory receptors on the surface of immune effector cells involved in allergic, inflammatory and proliferative diseases.
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Experience developing and working with various antibody discovery and protein engineering technologies such as mouse hybridoma, single B cell, phage/yeast/mammalian display, and/or computer-aided antibody/protein design is required.
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We combine this and other high-throughput protein engineering approaches with computational design to create antibody-like drugs and other biologics. This is a unique opportunity to work with world-class technologists innovating in cutting edge molecular biology and compute approaches to realize the potential of a novel protein engineering platform.
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Demonstrated experience in small molecule and protein mass-spectrometry of quantitation of antibody drug-conjugates (ADC), including total Antibody, Conjugated payload, and free payload.
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Strong understanding state-of-the-art methods and technologies used in the industry Tissue handling techniques for detection of gene and protein expression, including fixation, sectioning, IHC, histological staining, ISH MAbs/bi specifics - expertise in antibody protein structure & function, ability to apply protein engineering principles to mAb drug design.
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Innovate : Utilize your expertise in protein engineering to refine and optimize the processes involved in a variety of antibody development challenges. You have 1-3 years of hands-on experience in antibody discovery workflows via in-vitro display technology (yeast, phage, mammalian, etc.
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Bachelor's degree with experience in molecular biology, biochemistry, immunology, protein engineering, or a related discipline. + Flow cytometry for cell line characterization and antibody discovery.
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