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Extensive experience in flow cytometry, as well as molecular and cellular biology; Develop and execute efficient strategies for target identification, prioritization and validation; review, propose, initiate, and implement new pre-clinical therapeutic antibody drug discovery and development programs in the field of Immunology and Inflammation.
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The candidate must have demonstrable experience with antibody discovery and protein engineering programs in a biologics discovery setting. Extensive hands-on laboratory experience in all aspects of protein and antibody expression, purification, and characterization to support the preclinical discovery and development efforts of the biotherapeutics group.
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GenScript ProBio is the subsidiary of GenScript Biotech Corporation, proactively providing end-to-end CDMO service from drug discovery to commercialization with proactive strategies, professional solutions and efficient processes in cell and gene therapy (CGT), vaccine, biologics discovery and antibody protein drug to accelerate drug development for customers.
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Applying molecular and structural biology expertise to rationally design new bi- and multi-specific antibody based upon specific antigenic requirements. We are seeking a highly motivated Sr. Scientist with expertise in antibody and protein engineering, who will lead development of novel fit-for-purpose bi- and multi-specific antibodies for use in targeting of viral gene therapies.
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Large scale antibody, HIV-1 envelope and nanoparticle, and host protein production and purification. Molecular biology assays such as PCR, site-directed mutagenesis, DNA preparation. Sanger sequencing of plasmid DNAHIV-1 envelope and antibody sequence analysis.
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Evaluate novel technologies in antibody discovery and molecular biology to enhance and streamline discovery workflows. Visterra is a clinical stage biotechnology company committed to developing innovative antibody-based therapies for the treatment of patients with kidney diseases and other hard-to-treat diseases.
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If you thrive in a collaborative, fast-paced, problem-solving role, have confirmed experience in chemistry, biochemistry, immunochemistry, immunology, or cell biology and knowledge of immunoassay chemistry and development, and want to work to build world-class immunoassay products and systems-read on.
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Specific Duties & Responsibilities Uses molecular biology methods (cloning, PCR assays, mutagenesis), cell culture methods (transfections, virus infections, cell line maintenance), biochemical procedures (protein electrophoresis, western blotting, immunoprecipitation, protein purification, protein micro-array, immunofluorescence), recombinant herpes virus and baculovirus generation.
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Our preclinical pipeline extends beyond to biologics against novel immuno-oncology targets, antibody-drug conjugates, bispecific and trispecific antibodies, and small molecules expected to reach the clinic in 6-24 months, underscoring our bench-to-bedside approach.
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Minimum of 8-10 years of experience in protein engineering and intrabody/antibody discovery, with a proven track record of scientific achievement and leadership. Strong background in protein biochemistry, function/activity relationship of ubiquitinases/deubiquitinases, and structural biology ideally with experience in integral membrane protein expression.
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The successful candidate will play a key role in the development of promising anticancer therapeutics by leading process development, tech transfer, and manufacturing activities for conjugation and fill finish processes of ImmunoGen's novel antibody-drug conjugates.
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Our pipeline includes antibody-based therapeutics which have the ability to engage the human immune system and/or directly affect critical pathways to improve the lives of patients with severe inflammatory, allergic and autoimmune and other devastating diseases.
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As part of our mission, TRACTION is focused on partnering with our internal drug discovery engine (IACS, ORBIT, Biologics Development and Cell Therapies) and a growing list of external Partners (Boehringer Ingelheim, Taiho, Blueprint Medicines, Schrödinger and Obsidian) to discover and develop the next generation of small-molecule targeted therapies, antibody therapeutics and cell therapies, all driven by the needs we see in our patients.
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Additionally, the Senior Scientist will collaborate with the other Biologics and Biology Teams to provide protein material, characterization data and molecular biology support to move Tentarix’s project portfolio forward.
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PhD in Biochemistry, Molecular Biology, or a field related to Antibody Production and Screening or equivalent combination of education and relevant experience. Monitor antibody production cycle processes (including molecular, transfection, purification, filtration) and down-stream characterization (including binding, affinity, and structural) to ensure analytic performance and compliance with Quality Assurance/Quality Control requirements.
$159,330 - $204,636 a yearFull-timeExpandApply NowActive JobUpdated 2 days ago
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