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Scientist II/Senior Scientist I, Cell Screening

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THIRD ROCK VENTURES, LLCRedwood City, CA
  • Scientific expertise in high-throughput drug discovery cellular screening and relevant assay technologies (e.g. alphaLISA/MSD, TR-FRET/BRET, luminescence, high-content microscopy) and experience with data processing and visualization tools for large datasets (e.g. Genedata Screener, KNIME, D360, Spotfire).
  • Scientist II/Senior Scientist I, Cell Screening at Revolution Medicines Revolution Medicines is a clinical-stage precision oncology company focused on developing novel targeted therapies to inhibit elusive frontier targets within notorious growth and survival pathways, with particular emphasis on RAS and mTOR signaling pathways.
  • Required Experience, Skills, and Education: Ph. D. in Chemical Biology, Molecular/Cell Biology, Cancer Biology, or related field with 3 years postdoctoral or relevant biopharmaceutical industry research experience (job level commensurate with experience); industry experience in small molecule discovery is strongly preferred.
  • Familiarity with cancer signal transduction pathways, including RAS/MAPK pathway, is desired.
  • Proven track record of rigorous, quantitative and detail-oriented science with direct experience developing cellular assays with a variety of tissue/cell types and growth conditions; experience with 3D culture models is a plus.
  • Collaborate with chemists, biologists, and pharmacologists to generate pathway and SAR insights that fuel drug development and inform strategic program decisions.
  • As a member of the Biology Department and a key player in the Cancer Targets & Screening team, you will: Develop and deploy robust cellular screening assays to discover and characterize small molecule modulators of cancer target biology.
  • Implement best practices (automation, informatics, organization) to optimize screening processes.

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