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Research Scientist I / II

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Genomatica, IncSan Diego, CA
  • Title: Research Scientist I/II
  • Department: Enzyme Engineering
  • Genomatica is harnessing biology to remake everyday products and materials built by and for the planet.
  • The company is developing and scaling sustainable materials derived from plant- or waste-based feedstocks instead of fossil fuels to help brands deliver on their climate goals and our planet’s needs.
  • Genomatica has already commercialized sustainable materials used in plastics, spandex and cosmetics, and is working on plant-based nylon, household cleaners and more.
  • Genomatica is a widely-recognized technology leader for the chemical industry.
  • It delivers new manufacturing processes that enable its partners to produce the world’s most widely-used chemicals from alternative feedstocks with better economics and greater sustainability than petroleum-based processes.
  • The Enzyme Engineering team is responsible for the identification and improvement of enzymes, including mutagenesis library design and construction as well as purification, characterization, and screening/selection of engineered variants for the cost-advantaged production of chemicals using microorganisms.
  • The Enzyme Engineering Team is seeking a detail-oriented Scientist I to design enzyme mutagenesis libraries, develop and perform enzyme activity assays, and kinetically characterize purified enzymes in order to select improved variants for Genomatica’s production processes.
  • In addition, he or she will assist in cloning, expression, and bacterial growth procedures to enable said enzyme characterization.
  • Essential Functions and Responsibilities include the following.
  • Other duties may be assigned.
  • To perform this job successfully, an individual must be able to perform each essential duty satisfactorily.
  • Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.
  • Develop deep understanding of enzymes of interest and work with department and project teams to develop engineering strategies and tactics.
  • Design enzyme mutagenesis libraries using structural information when available.
  • Develop enzyme screening assays and use these assays to characterize enzyme variants to assess suitability for metabolic pathways.
  • Work with automation scientists to adapt biochemical assays to robotic platforms to enable high throughput screening to identify improved variants from primary screens for follow-up analysis in secondary screens and kinetic characterization.
  • Analyze data using statistical methods to inform future rounds of mutagenesis.
  • Maintain knowledge of current enzyme engineering methods and literature.
  • Support Intellectual Property Filings and interact with IP team.
  • Qualifications & Experience
  • The requirements listed below are representative of the knowledge, skill, and/or ability required in order satisfactorily perform in this role.
  • PhD in Biochemistry, Bioengineering, Chemical Engineering, Molecular Biology, or related scientific field with 0-2 years post-graduate experience.
  • Master’s with 6-8 years post-graduate experience, or Bachelor’s with 8 or more years of post-graduate experience
  • Experience and knowledge requirements
  • Track record of peer-reviewed publications
  • Relevant laboratory skills as demonstrated by academic and/or industrial research experience.
  • Deep understanding of enzyme mutagenesis library design principles and methods.
  • Experience with computational/rationally informed library design is preferred.
  • Proficiency in statistics, data processing, and experimental design.
  • Experience with protein expression, purification, and characterization including determination of kinetic parameters.
  • Desirable experience in high throughput assay development and automation.
  • Good time management and desire to work in an environment where success is dependent upon teamwork and communication.
  • Excellent organization and communication skills (both written and oral).
  • Work Environment/ Physical Demands
  • The work environment and physical demands described here are representative of those an employee encounters while performing the essential functions of this job.
  • This position involves working primarily in a laboratory setting.
  • As such, this position requires the ability to stand or sit at the bench and the use of standard laboratory equipment, computers, and office equipment.
  • The position requires communication with other individuals through a variety of methods.
  • Genomatica is committed to providing exciting career opportunities in an environment that values trust, respect, openness, teamwork, creativity, enthusiasm, and diligence.
  • We strive to create a culture that enables and encourages everyone to bring their whole selves to work.
  • We are committed to be a company where everyone feels they have equal opportunity to reach their potential.
  • Everyone is accepted and appreciated for who they are and what they bring to Genomatica.
  • We are looking for innovative, highly motivated, and collaborative people who enjoy the challenges and rewards of a company devoted to commercializing cutting-edge sustainable technology.
  • Check us out on our LinkedIn Life page.
  • Genomatica is an equal opportunity employer.
  • Qualified applicants will be considered without regard to race, color, religion, creed, sex, sexual orientation, gender identity, marital status, national origin, age, veteran status, disability or any other characteristic protected by law.

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