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Postdoctoral Fellow - Critical Care - Research
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$56,484 - $68,604 a year
Full-time
- A Postdoctoral position for an NIH-funded project is available at MD Anderson Cancer Center to study the mechanisms and identify novel adjuvant therapies to promote neutrophil extracellular trap (NET) formation in Chronic Granulomatous Disease (CGD), which is a primary immunodeficiency with defects in reactive oxygen species (ROS) generation capacity of phagocytes resulting in life-threatening acute and recurrent infections.
- This project will investigate new NET modulation strategies as effective treatment options for CGD and its inflammatory clinical manifestations.
- We seek a motivated and technically adept postdoctoral fellow to investigate signaling mechanisms of neutrophil extracellular trap formation in response to FDapproved drugs and their impact on acute and chronic bacterial infections in preclinical models of CGD. The highly translational project will require a commitment of 3 years that will also include working in close collaboration with investigators at NIH/NIAID and a well-defined cohort of CGD patients at NIH Clinical Center.
- The position requires hands-on experience in transgenic mouse models of pulmonary infection and disease, isolation, culture, and manipulation of primary immune cells, bacterial propagation techniques, multicolor flow cytometry, microscopy, immunostaining, and basic biochemical techniques.
- Design and implement research methods, resources, and instrumentation relevant to the assigned projects.
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